What are the effects of recombinant Factor VIIa on activated partial thromboplastin time (aPTT)?
  Administration of recombinant Factor VIIa shortens the prolonged aPTT in hemophilia A/B patients with inhibitors, normalization has usually not been observed in doses shown to induce clinical improvement. Data indicate that clinical improvement during recombinant Factor VIIa treatment was associated with a shortening of aPTT of 15 to 20 seconds.
 
 
     
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