What is the dosing regimen for recombinant Factor VIIa for hemophilia?
  The recombinant Factor VIIa dose for hemophilia A or B patients with inhibitors is 90 micrograms/kg intravenously given every 2 hours until hemostasis is achieved, irrespective of bleeding etiology or location. For severe bleeds in hemophilia patients with inhibitors, bolus dosing should continue at 3- to 6-hour intervals after hemostasis has been achieved in order to maintain the hemostatic plug. The biological and clinical effects of prolonged elevated levels of Factor VIIa have not been studied. Therefore, the duration of post-hemostatic treatment should be minimized, and a physician experienced in the treatment of hemophilia patients should appropriately monitor patients during prolonged bolus treatment with Recombinant Factor VIIa.
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